These types of vaccines use a harmless, weakened animal virus that contains the genetic code for a protein unique to COVID-19, usually the spike protein. Hosseinzadeh A, Ebrahimi K, Shahriarirad R, Dalfardi F. Clin Case Rep. 2022 Dec 15;10(12):e6317. The JAMA Dermatology report included a broader age range of 25 to 89, with the majority of people also identified as White and female. have ever fainted following any needle injection. Different individuals may respond to medication in different ways. Government activity Departments. One dose (0.5 mL) contains 100 micrograms of messenger RNA (mRNA) (embedded in SM-102 lipid nanoparticles). The Covid-19 vaccine is one example of how mRNA can be used. The study was also limited to a single medical center during a short period of time. MeSH an abnormal one at injection site), Injection site paraesthesia (abnormal skin sensations at injection site), Injection site pruritus (severe itching at injection site), Injection site urticaria (rash of round, red welts on the skin at injection site), Injection site vesicles (fluid- or air-filled cavity or sac at injection site), Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain), Joint range of motion decreased (disease of joint movement), Leukocytosis (increased white blood cells), Local reaction (reaction of any substance at the site of use), Lung consolidation (a condition whereby the lung tissues solidify because of the accumulation of solid and liquid material in the air spaces), Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung), Lymphadenitis (inflammation or enlargement of a lymph node), Lymph follicular hypertrophy (an increase in the size of the lymph node follicles), Lymphoedema (localized fluid retention and tissue swelling), Malaise (a feeling of general discomfort or uneasiness), Maternal exposure before pregnancy (use of substance before pregnancy), Maternal exposure during pregnancy (use of substance during pregnancy), Mechanical urticaria (urticaria is triggered by mechanical shearing forces e.g. March 2021. doi:10.1056/NEJMoa2035389, Johnston MS, Galan A, Watsky KL, Little AJ. All rights reserved. Following vaccination, you should be alert to signs of myocarditis and pericarditis, such as breathlessness, palpitations and chest pain, and seek immediate medical attention should these occur. Spikevax contains elasomeran, a molecule called messenger RNA (mRNA) with instructions for producing a protein from the original strain of SARS-CoV-2, the virus that causes COVID-19. Moderna said the agreement also required royalty payments representing low single-digit percentages of future Covid-19 vaccine sales. They were about 2.6 times as likely . You have accepted additional cookies. Moderna's coronavirus vaccine may cause alarming delayed side effects from its first dose among a portion of recipients. MB), Help with "It basically covered my whole shoulder," she said. New case reports and updated literature review. The phase IV clinical study analyzes which people get Moderna COVID Vaccine and have Cellulitis staphylococcal. 2022 Oct;132:102898. doi: 10.1016/j.jaut.2022.102898. We also use cookies set by other sites to help us deliver content from their services. Individuals should be observed by a healthcare professional for at least 15 minutes after vaccination. The dimensions of a carton of vaccine are 5.4" x 2.1" x 2.4". continue to maintain physical precautions to help prevent COVID-19. Opens in a new tab or window, Visit us on TikTok. The ChAdOx1 nCoV-19 vaccine contains recombinant adenoviral vectors encoding the spike protein of SARS-CoV-2, stabilisers, and immune adjuvant. COVID-19 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines. Charles Bankhead, Senior Editor, MedPage Today Moderna COVID-19 Vaccine is a monovalent COVID-19 vaccine that is authorized for emergency use to prevent COVID-19 as a: Two-dose primary series for individuals 6 months of age and. Incident systemic rheumatic disease following COVID-19. The Pfizer subgroup represented a smaller sample size (34 first-dose reports and 40 second-dose reports), but the pattern of skin reactions was similar to that observed with the Moderna vaccine. Less commonly, patients had episodes of zoster (shingles), herpes simplex flares, and rosacea-like reactions. Moderna has 24 mRNA vaccines and therapeutics under investigation, and 14 have begun clinical studies, according to the. swelling of your lips, face, tongue or throat, Swelling/tenderness of the underarm glands on the same side as the injection site, redness at the injection site (some of which may occur approximately 9 to 11 days after the injection), Rash or hives at the injection site (some of which may occur at a median of 4 to 11 days after the injection), raised, itchy rash (urticaria) (which may occur from the time of injection and up to approximately two weeks after the injection), Temporary one sided facial drooping (Bells palsy), Swelling of the face (Swelling of the face may occur in patients who have had facial cosmetic injections. 8600 Rockville Pike Cutaneous adverse reactions following COVID-19 vaccinations: A systematic review and meta-analysis. A new study finds some of them, including COVID toes, a measleslike rash and shingles also can be rare, and thankfully brief, side . A wide range of skin reactions has occurred following coronavirus vaccination -- including some that mimic COVID-19 symptoms -- but none proved to be serious, according to initial data from an international registry. This is not a complete list of side effects and others may occur. Established in March 2020 to accumulate information on cutaneous manifestations of COVID-19, the registry expanded in December to include vaccine-related skin reactions, shortly after the FDA issued the first emergency use authorizations (EUAs) for the vaccines. During and after each injection of the vaccine, your doctor, pharmacist or nurse will watch over you These can include: If you get any side effects, talk to your doctor, pharmacist or nurse. Would you like email updates of new search results? Bookshelf Accessibility If you have previously had episodes of CLS, talk to a doctor before you are given Spikevax. Moderna Inc will make certain contingent development, commercial and regulatory milestone payments to the U.S. National Institutes of Health (NIH) related to the development of COVID-19 vaccines . Before The vaccine comes ready to use once thawed. A survey of more than 40,000 healthcare employees at Mass General Brigham who received either the Moderna or Pfizer COVID-19 vaccines, found that 1.9% reported itching, rash, hives, or swelling after the first dose. Please enable it to take advantage of the complete set of features! Additionally, five people died after receiving a jab from an. . COVID-19 vasculitis and novel vasculitis mimics. Four vaccines are approved by the European Medicines Agency: two messenger RNA-based vaccines encoding the spike protein of SARS-CoV-2 (BNT162b2, PfizerBioNTech; mRNA-1273, Moderna) and two adenoviral vector-basedvaccines encoding the spike protein (ChAdOx1 nCoV-19, AstraZeneca; Ad.26.COV2.S, Janssen). The centre will create hundreds of jobs and make 100 million vaccines . HHS Vulnerability Disclosure, Help eCollection 2022 Oct. Bose P, Goenka U, Moitra S, Majumdar S, Goenka MK, Sen SG. Perspective of patients with autoimmune diseases on COVID-19 vaccination. The phase IV clinical study analyzes which people get Moderna COVID Vaccine and have Cellulitis staphylococcal. And it started to spread." Pendlebury GA, Oro P, Haynes W, Merideth D, Bartling S, Bongiorno MA. In a study published in the NEJM in February, 2021, the investigators reported that 12,765 (84.2%) of the 15,168 participants who had received the vaccine rather than the placebo developed an immediate skin reaction after receiving their first dose of the vaccine. HHS Vulnerability Disclosure, Help Epub 2022 Aug 1. Charles Bankhead is senior editor for oncology and also covers urology, dermatology, and ophthalmology. He joined MedPage Today in 2007. As of Sept 23, 2021, more than 83 million vaccine doses were administered in Italy, with approximately a fifth of recipients receiving ChAdOx1 nCoV-19 vaccine. The company has forecast Covid vaccine sales of $5 billion for . The site is secure. Follow. Spikevax uses a substance called messenger ribonucleic acid (mRNA) to carry instructions that cells in the body can use to make the spike protein that is also on the virus. "I think this is particularly interesting because it shows that the body is mounting an immune response to the vaccine, just as it does after infection with the virus," said Freeman. Sixty-year-old woman (patient 1) 24h after initiation of topical steroid treatment; the left arm showed a dramatic decrease in erythema and swelling. While information on effects on pregnancy or the newborn baby after vaccination during the first trimester is limited, no change to the risk for miscarriage has been seen. The vaccine also demonstrated efficacy in preventing severe COVID-19. feeling faint or light-headed changes in your heartbeat shortness of breath wheezing swelling of your lips, face, tongue or throat hives or rash nausea or vomiting stomach pain Talk to your doctor. Measles-like morbilliform rash occurred after the first dose of Moderna vaccine in 4.1% of patients and after the second dose in 6.9%. Erythromelalgia occurred after 5.9% of second doses, and cosmetic filler reactions occurred after 4.9% of second doses. 6th ed. Epub 2020 Jul 23. Spain, Rovi Pharma Industrial Services, S.A. Federal government websites often end in .gov or .mil. doi: 10.1093/ofid/ofac499. doi: 10.1002/ccr3.6314. JAMA Dermatol. 2021 Elsevier Ltd. All rights reserved. Normal skin can be affected by cellulitis, but it usually happens after some type of injury causes a skin break, including trauma or surgery. People aged 16 and over, and some children aged 12 to 15, can also get a booster dose. Received vaccine (at least 1 dose) 312 (94.8%) Moderna 122 (39.1% . Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. How to treat COVID-19 vaccine injection site pain. The coronavirus (COVID-19) vaccines are safe and effective. Spikevax vials are multidose. 2023 eHealthMe.com. Common Moderna COVID-19 Vaccine side effects may include: fever, chills; redness or a hardness and swelling where the shot was given; swelling or tenderness under your arm; nausea, vomiting; feeling tired; or. Do not use this vaccine after the expiry date which is stated on the label after EXP. Scan the code in the PDF of this document with a mobile device to get the package leaflet in different languages. "Understandably, the clinical trials were focused on their major endpoints and didn't really provide a lot of detail on the skin reactions seen in patients.". The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Distinguishing features of COVID arm from cellulitis include pruritus as a common finding, occurrence approximately a week after vaccination, a lack of progression of symptoms, rapid response to topical steroids, and/or spontaneous resolution usually over 4 to 5 days.Practice Points: Patients receiving SARS-CoV-2 vaccines may experience delayed hypersensitivity reactions characterized by erythema, swelling, and itching occurring near the vaccination site (COVID arm), approximately a week after vaccination. Clinicians can distinguish SARS-CoV-2 vaccine reactions from cellulitis by the time of onset (approximately a week vs 5 days), by the lack of progression of symptoms, and resolution over 4 to 5 days. Severe cases of COVID arm may be treated with topical steroids. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. This includes any possible side effects not listed in this leaflet. Accessed April 28, 2021. Keywords: Moderna said people without insurance will be able to get its COVID vaccine at no cost after the U.S. government bows out. Clipboard, Search History, and several other advanced features are temporarily unavailable. Well send you a link to a feedback form. 2022 Sep 27;9(10):ofac499. A booster dose (0.25 mL, 50 micrograms) of Spikevax may be given at least 3 months after a primary Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. The site is secure. Opens in a new tab or window, Visit us on Instagram. Vaccines against SARS-CoV-2 represent a pivotal and effective countermeasure to contain the COVID-19 pandemic. The active substance in Spikevax is mRNA encoding the SARS-CoV-2 Spike protein. If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. Guidance and regulation Local injection-site reactions occurred after 24% and 25% of first and second doses, respectively. COVID-19 vaccine-associated myositis - a case report. Access the latest 2019 novel coronavirus disease (COVID-19) content from across The Lancet journals as it is published. American Medical Association. If you do develop one, don't panic. Audio will be available later today. N Engl J Med. We declare no competing interests. JAMA Dermatol. If you have itching, swelling, or tenderness at the injection site in the days after getting either dose of the vaccine, don't panic. Clipboard, Search History, and several other advanced features are temporarily unavailable. According to the FDA,. This will allow quick identification of new safety information. In a letter to the editor published in The New England Journal of Medicine (NEJM) on March 3, 2021, researchers reported on a dozen people who developed skin redness, skin thickening and swelling, tenderness, or some combination of these symptoms at the injection site between four and 11 days after receiving their first dose of the Moderna COVID-19 vaccine. Painful, pruritic, indurated, erythematous plaque with minute papules inferior to ecchymoses at the vaccine site on the left arm of a 60-year-old woman (patient 1) occurring 6days after the first vaccine dose. Reasons Behind Breast Pain After the COVID-19 Vaccine, Psoriasis and COVID-19 Vaccine: What to Know. She has previously written for publications including Insider and Cancer Health. 2022 Jul 16;10(7):1135. doi: 10.3390/vaccines10071135. Tel: 0800 085 7562. Open Forum Infect Dis. 1 Local reactions include mild to moderate pain at the injection site, and systemic side effects like fatigue, headache, and fever have been common after 2021 Nov 4;165:D6313. This particular reaction is characterized by pain and swelling in the upper arm located at the injection site appearing 7 to 8 days following injection. If you have any further questions on the use of this vaccine, ask your doctor, pharmacist or nurse. official website and that any information you provide is encrypted Getting COVID-19 can cause all manner of odd skin reactions. Caroline Tien is a journalist with degrees in English and biology. Spikevax may affect the way other medicines work, and other medicines may affect how Spikevax works. Moderna on Friday filed patent infringement lawsuits against Pfizer and BioNTech "for infringing patents central to (its) mRNA technology platform," the company said in a news release Friday. 2021 Nov 13;114(9):659-660. doi: 10.1093/qjmed/hcab161. official website and that any information you provide is encrypted If you are immunocompromised, you may receive a third dose of Spikevax. In order to improve the traceability of biological medicinal products, the name and the batch number of the administered product should be clearly recorded. For the most recent updates on COVID-19, visit our coronavirus news page. * Approximation only. This is a multidose vial that contains 10 doses of 0.5 mL each or a maximum of 20 doses of 0.25mL each. Vaccine Types. A booster dose (0.25 mL) of Spikevax may be given at least 3 months after the second dose in Spikevax is is a white to off white dispersion supplied in a glass vial with a rubber stopper and aluminium seal. The Impact of COVID-19 Pandemic on Dermatological Conditions: A Novel, Comprehensive Review. Breast Cancer and the COVID-19 Vaccine: Is It Safe? COVID vaccines that are related to Vulval cellulitis: Vulval cellulitis in Moderna COVID Vaccine; Vulval cellulitis in Pfizer BioNTech Covid Vaccine; Vulval cellulitis in Johnson and Johnson Covid Vaccine Delayed localized hypersensitivity reactions to the Moderna COVID-19 vaccine: a case series. While the coronavirus 2019 (COVID-19) vaccine is currently being rolled out, some vaccine recipients are experiencing adverse effects (AEs), one of which includes a delayed large local reaction. Q:. Cellulitis staphylococcal in Pfizer BioNTech COVID Vaccine, Cellulitis staphylococcal in Johnson & Johnson COVID Vaccine, Abortion spontaneous (naturally occurring miscarriage), Acute myocardial infarction (acute heart attack), Ageusia (loss of taste functions of the tongue), Agitation (state of anxiety or nervous excitement), Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death), Angioedema (rapid swelling of the dermis), Appendicitis (inflammation of the appendix), Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat), Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires), Arthritis (form of joint disorder that involves inflammation of one or more joints), Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem), Atelectasis (partial or complete collapse of the lung), Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles), Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue), Belching (release of gas from the digestive tract), Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure), Blood thyroid stimulating hormone decreased, Bradycardia (abnormally slow heart action), Breast lump (localized swelling that feels different from the surrounding breast tissue), Bronchitis (inflammation of the mucous membrane in the bronchial tubes), Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder), Canker sores (painful, open sore in the mouth), Cardiomyopathy (weakening of the heart muscle), Cardio-respiratory arrest (sudden dysfunction of heart and lungs), Cerebral haemorrhage (bleeding within the brain), Cerebral infarction (less blood supply to brain resulting tissue damage), Chapped lips (cracking, fissuring, and peeling of the skin f lip), Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe), Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving), Concussion (short loss of normal brain function in response to a head injury), Coronary heart disease (narrowing or blockage of the coronary arteries), Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis), Dehydration (dryness resulting from the removal of water), Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it), Dermatitis allergic (inflammation of the skin due allergic reaction), Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens), Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall), Dyskinesia (abnormality or impairment of voluntary movement), Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear), Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters), Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat), Ejection fraction decreased (systolic heart failure), Encephalopathy (functioning of the brain is affected by some agent or condition), Erythema multiforme (a type of hypersensitivity reaction), Euphoric mood (excessively happy but may become angry or irritable), Eyelid ptosis (falling of the upper or lower eyelid), Eyelid twitch (spontaneous and uncontrolled spasms of the muscles), Facial paralysis (loss of function of face muscle), Facial paresis (weakness in facial muscle movement), Fainting (loss of consciousness and postural tone), Feeding disorder (when children refuse to eat certain food groups), Fibromyalgia (a long-term condition which causes pain all over the body), Flank pain (a distressing sensation experienced around the lower back and the upper abdomen), Flatulence (flatus expelled through the anus), Fluid retention (an abnormal accumulation of fluid in the blood), Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin), Gallstones (stone formation by bile component), Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus), Gastrointestinal disorder (functional problems of gastrointestinal tract), Gastrointestinal haemorrhage (bleeding gastrointestinal tract), General physical health deterioration (weak health status), Glossodynia (a burning or painful sensation in the tongue), Gout (uric acid crystals building up in the body), Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system), Haematochezia (passage of stools containing blood), Haematoma (collection of blood outside the blood vessels), Hallucinations (sensations that appear real but are created by your mind), Heart palpitations (feelings or sensations that your heart is pounding or racing), Hemiparesis (weakness on one side of the body), Hemiplegia (paralysis of one side of the body), Herpes simplex (herpes simplex is a common viral infection), Hyperacusis (disorder in loudness perception), Hyperhidrosis (abnormally increased sweating), Hyperkalemia (damage to or disease of the kidney), Hypoaesthesia (reduced sense of touch or sensation), Hypoaesthesia oral (reduced sense of touch or sensation in mouth), Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration), Hypotension (abnormally low blood pressure), Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development), Idiopathic or primary livedo reticularis (netlike pattern of reddish-blue skin discoloration, usually on the legs), Incoherent (talking in a confused and unclear way), Incontinence (lack of moderation or self-control), Injection site cellulitis (injection site inflammation), Injection site erythema (redness at injection site), Injection site haemorrhage (bleeding from injection site), Injection site nodule (small swelling or aggregation of cells in the body, esp. 2020 Dec 1;16(12):2891-2904. doi: 10.1080/21645515.2020.1788310. -. While usually short-lived, these skin reactions can cause significant discomfort and are likely to generate concerns among patients and requests for evaluation, the researchers wrote in the NEJM letter, recounting a case in which a reaction was mistaken for the bacterial infection cellulitis and medicated with antibiotics. Most of the reactions were mild and resolved on their own. Published 2021. Moderna COVID-19 Vaccine is a monovalent COVID-19 vaccine that is authorized for emergency use to prevent COVID-19 as a: Two-dose primary series for individuals 6 months of age and. COVID-19 vaccine efficacy and effectiveness-the elephant (not) in the room. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). The authors explained that the small sample size limited their ability to identify any differences in the appearance of the reaction between races and ethnicities. Cellulitis staphylococcal is reported only by a few people who get Moderna COVID Vaccine. The initial series of both vaccines are given in two doses for ages 5 and older, and three doses for children ages 6 months through 4 years. doi: 10.1002/ccr3.6317. Cardiovascular symptoms, including faintness, syncope, altered mental status, palpitations, and hypotension. A third dose may be given at least 1 month after the second dose to individuals 12 years of age and older (0.5 mL, 100 micrograms) and children 6 through 11 years (0.25 mL, 50 micrograms) who are severely immunocompromised. They vary in appearance and size and can sometimes cover most of the upper arm. Viruses. A review of 414 skin reactions associated with the Moderna and Pfizer vaccines showed a variety of rashes, eruptions, and injection-site inflammation. Although we cannot exclude the possibility that the onset of vasculitis following vaccination was coincidental, striking similarities between these three patients argue for pathogenic causality. 2021 Sep;20(9):2684-2690. doi: 10.1111/jocd.14312. Keep this vaccine out of the sight and reach of children. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine: supplementary appendix. Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. The Centers for Disease Control and Prevention (CDC) now recommends that all individuals 5 years old who have completed a primary COVID-19 vaccine series (including those who already received booster doses with monovalent vaccines) receive a single booster dose with one of the bivalent vaccines at least two months after the last vaccine dose; bivalent booster recommendations for children . We saw the reactions on different skin tones but did not see any reaction on dark skin," Saff says. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. 2022 Sep;21(9):3636-3650. doi: 10.1111/jocd.15261. Spikevax is a vaccine used to prevent COVID-19 caused by SARS-CoV-2. Symptoms of COVID arm include: itching, which can be intense a red or discolored rash that varies in size from quarter-sized to very large in some instances, the rash may spread to your hands or. COVID-19 - Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines. Published 2021. MODERNA BIOTECH SPAIN, S.L. Opens in a new tab or window, Visit us on LinkedIn. Both the Pfizer and Moderna vaccines are approved for ages 6 months and older. Do not drive or use machines if you are feeling unwell after vaccination. If you have itching, swelling, or tenderness at the injection site in the days after getting either dose of the vaccine, don't panic. They also stress that concerns about a skin reaction should not keep people from getting vaccinated. Monts, France 37260, Moderna Biotech Spain S.L. Moderna COVID Vaccine and Cellulitis staphylococcal - a phase IV clinical study of CDC and FDA data Summary: Cellulitis staphylococcal is reported only by a few people who get Moderna COVID Vaccine. Subcutaneous injections can lead to localised cellulitis, granuloma formation and abscess. If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. See this image and copyright information in PMC. It is recommended to get the second dose 28 days after the first dose to complete the vaccination course. A new COVID-19 vaccine from Moderna targeting Omicron variants BA.4 and BA.5 will land in April. However, laboratory tests showed only non-specific increases in erythrocyte sedimentation rate and C-reactive protein (CRP); anti-neutrophil cytoplasmic antibodies, cytoplasmic anti-neutrophil cytoplasmic antibodies, perinuclear anti-neutrophil cytoplasmic antibodies, rheumatoid factor, cryoglobulins, antinuclear antibodies, anti-DNA, C3, C4, IgA, and serology for hepatitis B virus and hepatitis C virus were negative or normal. What you need to know before you are given Spikevax, Contents of the pack and other information, Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, Regulatory approval of Spikevax (formerly COVID-19 Vaccine Moderna), Package leaflet: Information for the user, The following information is intended for healthcare professionals only, nationalarchives.gov.uk/doc/open-government-licence/version/3. Privacy PolicyTerms and ConditionsAccessibility, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy, Division of Rheumatology, Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University, Rome, Italy, Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy. Why vaccines go into your upper arm and not up your nose The first COVID-19 jabs . Caroline Tien is a journalist with degrees in English and biology. "Side effects that have been reported with the Moderna COVID-19 Vaccine include: Injection site reactions: pain, tenderness and swelling of the lymph nodes in the same arm of the injection, swelling (hardness), and redness. 1 Injection site pain, redness, or swelling Both the Moderna vaccine and the Pfizer vaccine may produce a reaction around the area on your arm where you got your shot.